Some women have wondered why Dr. Lark chose Indole-3 Carbinol (I3C) over Diindolylmethane (DIM) for her menopause relief formula, Harmony. Both I3C and DIM do the exact same thing, converting estrogen into beneficial metabolites, with clinical evidence to support them. DIM, however, is poorly absorbed, making it necessary to use special forms available on the market that enhance its bioavailability. These special forms do not work well in a multi-ingredient formula, and is about ten times the cost of I3C. I3C is effective, affordable, and compatible with the other ingredients in Harmony, which is why Dr. Lark ultimately chose it over DIM.